| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities. |
| Protein Name | Exosome Complex Exonuclease Rrp44Protein Dis3 HomologRibosomal Rna-Processing Protein 44 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-429958Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-450604Reactome: R-HSA-6791226 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmPredominantly Located In The NucleusFound In The NucleolusExcluded From Nucleolus Supporting The Existence Of A Nucleolar Rna Exosome Complex Devoid Of Dis3 |
| Alternative Protein Names | Exosome Complex Exonuclease Rrp44 proteinProtein Dis3 Homolog proteinRibosomal Rna-Processing Protein 44 proteinDIS3 proteinKIAA1008 proteinRRP44 protein |
Information sourced from Uniprot.org
