Human DHODH protein (Recombinant) (His-Tag) (STJP017724)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DHODH-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHODH |
| Gene ID | 1723 |
| Uniprot ID | PYRD_HUMAN |
| Accession Number | NP_001352 |
| Immunogen | Human |
| Immunogen Region | 31-395aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMTGDER FYAEHLMPTL QGLLDPESAH RLAVRFTSLG LLPRARFQDS DMLEVRVLGH KFRNPVGIAA GFDKHGEAVD GLYKMGFGFV EIGSVTPKPQ EGNPRPRVFR LPEDQAVINR YGFNSHGLSV VEHRLRARQQ KQAKLTEDGL PLGVNLGKNK TSVDAAEDYA EGVRVLGPLA DYLVVNVSSP NTAGLRSLQG KAELRRLL |
Additional Info
| Post Translational Modifications | The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration. |
| Function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. |
| Protein Name | Dihydroorotate DehydrogenaseQuinone - MitochondrialDhodehaseDihydroorotate Oxidase |
| Database Links | Reactome: R-HSA-500753 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Dihydroorotate Dehydrogenase proteinQuinone - Mitochondrial proteinDhodehase proteinDihydroorotate Oxidase proteinDHODH protein |
Information sourced from Uniprot.org