Human DGKE protein (Recombinant) (N-His) (STJP004897)

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STJP004897
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DGKE-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DGKE
Gene ID: 8526
Uniprot ID: DGKE_HUMAN
Immunogen Region: Leu243-Gly502
Immunogen: Homo sapiens (Human)
Function Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently.
Protein Name Diacylglycerol Kinase Epsilon
Dag Kinase Epsilon
Diglyceride Kinase Epsilon
Dgk-Epsilon
Database Links Reactome: R-HSA-114508
Cellular Localisation Membrane
Single-Pass Membrane Protein
Cytoplasm
Alternative Protein Names Diacylglycerol Kinase Epsilon protein
Dag Kinase Epsilon protein
Diglyceride Kinase Epsilon protein
Dgk-Epsilon protein
DGKE protein
DAGK5 protein

Information sourced from Uniprot.org

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