Human DEFB126 protein (Recombinant) (N-GST) (STJP005956)

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STJP005956
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DEFB126-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DEFB126
Gene ID: 81623
Uniprot ID: DB126_HUMAN
Immunogen Region: Asn21-Gly111
Immunogen: Homo sapiens (Human)
Post Translational Modifications O-glycosylated.glycans contain alpha(2,3)-linked sialic acids.
Function Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection.both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte. In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation.
Protein Name Beta-Defensin 126
Beta-Defensin 26
Defb-26
Defensin - Beta 126
Epididymal Secretory Protein 13.2
Esp13.2
Hbd26
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Secreted By Epididymal Cells And Is Absorbed To The Surface Of Sperm During Transit Through The Epididymis
Mainly Located On The Sperm Acrosome
Alternative Protein Names Beta-Defensin 126 protein
Beta-Defensin 26 protein
Defb-26 protein
Defensin - Beta 126 protein
Epididymal Secretory Protein 13.2 protein
Esp13.2 protein
Hbd26 protein
DEFB126 protein
C20orf8 protein
DEFB26 protein

Information sourced from Uniprot.org

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