Human DEFA5 protein (Recombinant) (N-His) (STJP005129)

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STJP005129
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human DEFA5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: DEFA5
Gene ID: 1670
Uniprot ID: DEF5_HUMAN
Immunogen Region: Glu20-Arg94
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. Proteolytically cleaved at Arg-62 by trypsin. Both the propeptide form proHD5/HD5(20-94) and HD5(56-94) are cleaved into the lumenal peptide form HD5(63-94) by trypsin. Unprocessed proHD5 exerts antimicrobial activities, but peptide potency is enhanced by peptide processing. Proteolytically cleaved in duodenal fluid.derived fragments are antimicrobially active against commensal bacteria (in vitro). (Microbial infection) The disulfide bridges and homodimerization are a prerequisite for the enhancement of S.flexneri adhesion and invasion.
Function Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. Induces the secretion of the chemokine IL-8 by intestinal epithelial cells. Binds to B.antracis lef/lethal factor, a major virulence factor from B.anthracis, and neutralizes its enzymatic activity. (Microbial infection) Acts as a target for S.flexneri infection by binding to the bacterium, possibly via bacterial surface proteins, and thereby augmenting infectivity via enhanced bacterial adhesion and invasion of epithelial cells and tissues.
Protein Name Defensin Alpha 5
Defensin-5
Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94
Database Links Reactome: R-HSA-1461973
Reactome: R-HSA-1462054
Cellular Localisation Secreted
Cytoplasmic Vesicle
Secretory Vesicle
Stored As Propeptide Hd5(20-94) In Secretory Granules Of Small Intestinal Paneth Cells And Found In The Ileum Lumen As Processed Mature Peptides
Predominantly In The Hd5(63-94) Form
Peptides Hd5(20-94)
Hd5(23-94) And Hd5(29-94) Are Found Within Tissues
Hd5(20-94) Being The Predominant Intracellular Form
Peptides Hd5(56-94) And Hd5(63-94) Are Found In The Extracellular Milieu
Hd5(63-94) Being The Most Abundant Form
Secreted Into The Female Genital Tract Lumen
Alternative Protein Names Defensin Alpha 5 protein
Defensin-5 protein
Hd5(20-94 Cleaved Into - Hd5(23-94 - Hd5(29-94 - Hd5(56-94 - Hd5(63-94 protein
DEFA5 protein
DEF5 protein

Information sourced from Uniprot.org

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