Human DEF Beta 2/DEFB2 (Defensin Beta 4a) Antibody Pair (STJAP00420)

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STJAP00420-50
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Host: Goat/Goat
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This DEF Beta 2/DEFB2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: DEFB4A.DEFB4B
Gene ID: 100289462/1673
Uniprot ID: DFB4A_HUMAN
Immunogen: Capture immunogen: Recombinant Human DEF Beta 2/DEFB2 protien.
Detection Immunogen: Recombinant Human DEF Beta 2/DEFB2 protien.
Sample Type: Serum, plasma and other biological fluids
Function Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells, such as immature dendritic cells and memory T cells.
Protein Name Defensin Beta 4a
Beta-Defensin 2
Bd-2
Hbd-2
Defensin - Beta 2
Skin-Antimicrobial Peptide 1
Sap1
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-1461973
Cellular Localisation Secreted
Alternative Antibody Pair Names Defensin Beta 4a antibody pair
Beta-Defensin 2 antibody pair
Bd-2 antibody pair
Hbd-2 antibody pair
Defensin - Beta 2 antibody pair
Skin-Antimicrobial Peptide 1 antibody pair
Sap1 antibody pair
DEFB4A antibody pair
DEFB102 antibody pair
DEFB2 antibody pair
DEFB4.DEFB4B antibody pair

Information sourced from Uniprot.org

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