Human DDX39A protein (Recombinant) (His-Tag) (STJP018815)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human DDX39A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DDX39A |
| Gene ID | 10212 |
| Uniprot ID | DX39A_HUMAN |
| Accession Number | NP_005795 |
| Immunogen | Human |
| Immunogen Region | 1-249aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSEFMAEQD VENDLLDYDE EEEPQAPQES TPAPPKKDIK GSYVSIHSSG FRDFLLKPEL LRAIVDCGFE HPSEVQHECI PQAILGMDVL CQAKSGMGKT AVFVLATLQQ IEPVNGQVTV LVMCHTRELA FQISKEYERF SKYMPSVKVS VFFGGLSIKK DEEVLKKNCP HVVVGTPGRI LALVRNRSFS LKNVKHFVLD ECDKMLEQ |
Additional Info
| Tissue Specificity | Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland. |
| Post Translational Modifications | SUMOylated by RANBP2.SUMOylation modification affects its ability to bind RNA. |
| Function | Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA. |
| Protein Name | Atp-Dependent Rna Helicase Ddx39aDead Box Protein 39Nuclear Rna Helicase Urh49 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72187Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusCytoplasmCan Translocate To The Cytoplasm In The Presence Of Mx1Accumulates In The Cytoplasm Upon Infection With Chikungunya Virus |
| Alternative Protein Names | Atp-Dependent Rna Helicase Ddx39a proteinDead Box Protein 39 proteinNuclear Rna Helicase Urh49 proteinDDX39A proteinDDX39 protein |
Information sourced from Uniprot.org