| Function | Diacylglycerol (DAG) and triacylglycerol (TAG) lipase required for proper lipid homeostasis in the central nervous system. It cooperates with PNPLA2/ATGL in neuronal TAG catabolism and hydrolyzes sn-1,3 DAG downstream of PNPLA2/ATGL. In vitro, it also acts as a phospholipase that hydrolyzes preferentially phosphatidic acids, including 1,2-dioleoyl-sn-phosphatidic acid, phosphatidylcholine and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane. |
| Protein Name | Triacylglycerol Hydrolase Ddhd2Tag HydrolaseDdhd Domain-Containing Protein 2Kiaa0725pPhospholipase Ddhd2Sam - Wwe And Ddhd Domain-Containing Protein 1Triglyceride Hydrolase Ddhd2Triglyceride Lipase |
| Database Links | Reactome: R-HSA-1483166 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum-Golgi Intermediate CompartmentGolgi ApparatusCis-Golgi NetworkCycles Between The Golgi Apparatus And The CytosolDdhd2 Recruitment To The Golgi/Endoplasmic Reticulum-Golgi Intermediate Compartment (Ergic) Is Regulated By The Levels Of PhosphoinositidesIncluding Pi(4)P |
| Alternative Protein Names | Triacylglycerol Hydrolase Ddhd2 proteinTag Hydrolase proteinDdhd Domain-Containing Protein 2 proteinKiaa0725p proteinPhospholipase Ddhd2 proteinSam - Wwe And Ddhd Domain-Containing Protein 1 proteinTriglyceride Hydrolase Ddhd2 proteinTriglyceride Lipase proteinDDHD2 proteinKIAA0725 proteinSAMWD1 protein |
Information sourced from Uniprot.org
