Human DCUN1D1 protein (Recombinant) (N-His) (STJP014800)

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STJP014800-100
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Short Description :Recombinant-Human DCUN1D1-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:DCUN1D1
Gene ID:54165
Uniprot ID:DCNL1_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Val259
Post Translational Modifications Mono- and poly-ubiquitinated by ARIH2 and ARIH1. Monoubiquitination by ARIH2 is mediated by an interaction between autoubiquitinated ARIH2 and the UBA-like domain. The monoubiquitinated form preferentially interacts with non-neddylated cullins and modulates cullin RING ligase (CRL) complex composition and activity.
Function Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Also acts as an oncogene facilitating malignant transformation and carcinogenic progression.
Protein Name Dcn1-Like Protein 1
Dcnl1
Dcun1 Domain-Containing Protein 1
Defective In Cullin Neddylation Protein 1-Like Protein 1
Squamous Cell Carcinoma-Related Oncogene
Database Links Reactome: R-HSA-8951664
Cellular Localisation Nucleus
Cytoplasm
The Ubiquitinated Form Is Localized In The Cytoplasm
Alternative Protein Names Dcn1-Like Protein 1 protein
Dcnl1 protein
Dcun1 Domain-Containing Protein 1 protein
Defective In Cullin Neddylation Protein 1-Like Protein 1 protein
Squamous Cell Carcinoma-Related Oncogene protein
DCUN1D1 protein
DCN1 protein
DCUN1L1 protein
RP42 protein
SCCRO protein

Information sourced from Uniprot.org

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