Human Cytosolic beta-Glucosidase/GBA3 protein (Recombinant) (His-Tag) (STJP018942)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Cytosolic beta-Glucosidase/GBA3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GBA3 |
| Gene ID | 57733 |
| Uniprot ID | GBA3_HUMAN |
| Accession Number | NP_066024 |
| Immunogen | Human |
| Immunogen Region | 1-469aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor. Could also play a role in the catabolism of cytosolic sialyl free N-glycans. |
| Protein Name | Cytosolic Beta-GlucosidaseCytosolic Beta-Glucosidase-Like Protein 1Cytosolic GalactosylceramidaseCytosolic GlucosylceramidaseCytosolic GlycosylceramidaseCytosolic GcaseGlucosidase Beta Acid 3Glucosylceramidase Beta 3Klotho-Related ProteinKlrp |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Protein Names | Cytosolic Beta-Glucosidase proteinCytosolic Beta-Glucosidase-Like Protein 1 proteinCytosolic Galactosylceramidase proteinCytosolic Glucosylceramidase proteinCytosolic Glycosylceramidase proteinCytosolic Gcase proteinGlucosidase Beta Acid 3 proteinGlucosylceramidase Beta 3 proteinKlotho-Related Protein proteinKlrp proteinGBA3 proteinCBG proteinCBGL1 protein |
Information sourced from Uniprot.org