| Tissue Specificity | |
| Post Translational Modifications | |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position. Catalyzes the epoxidation of double bonds of PUFA. Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol. Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position. |
| Protein Name | Cytochrome P450 2c19(R-Limonene 6-Monooxygenase(S-Limonene 6-Monooxygenase(S-Limonene 7-MonooxygenaseCypiic17Cypiic19Cytochrome P450-11aCytochrome P450-254cFenbendazole Monooxygenase4'-HydroxylatingMephenytoin 4-Hydroxylase |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-2142670Reactome: R-HSA-2142816Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative ELISA Names | Cytochrome P450 2c19 ELISA kit(R-Limonene 6-Monooxygenase ELISA kit(S-Limonene 6-Monooxygenase ELISA kit(S-Limonene 7-Monooxygenase ELISA kitCypiic17 ELISA kitCypiic19 ELISA kitCytochrome P450-11a ELISA kitCytochrome P450-254c ELISA kitFenbendazole Monooxygenase ELISA kit4'-Hydroxylating ELISA kitMephenytoin 4-Hydroxylase ELISA kitCYP2C19 ELISA kit |
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Information sourced from Uniprot.org
