Human CYP26A1 protein (Recombinant) (N-His) (STJP003257)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CYP26A1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CYP26A1 |
| Gene ID | 1592 |
| Uniprot ID | CP26A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg73-Ile255 |
Additional Info
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid. |
| Protein Name | Cytochrome P450 26a1Cyp26a1Cytochrome P450 Retinoic Acid-Inactivating 1Cytochrome P450raiHp450raiRetinoic Acid 4-HydroxylaseRetinoic Acid-Metabolizing Cytochrome |
| Database Links | Reactome: R-HSA-211916Reactome: R-HSA-5365859 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Protein Names | Cytochrome P450 26a1 proteinCyp26a1 proteinCytochrome P450 Retinoic Acid-Inactivating 1 proteinCytochrome P450rai proteinHp450rai proteinRetinoic Acid 4-Hydroxylase proteinRetinoic Acid-Metabolizing Cytochrome proteinCYP26A1 proteinCYP26 proteinP450RAI1 protein |
Information sourced from Uniprot.org