| Host: | E.coli |
| Applications: | SDS-PAGE/Enzyme Activity |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Cyclophilin-like 1/PPIL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Specific activity is > 700nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin. |
| Gene Symbol: | PPIL1 |
| Gene ID: | 51645 |
| Uniprot ID: | PPIL1_HUMAN |
| Immunogen Region: | 1-166aa |
| Accession Number: | NP_057143 |
| Immunogen: | Human |
| Immunogen Sequence: | MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSG |
| Tissue Specificity | Ubiquitous, with the most abundant expression in heart and skeletal muscle. |
| Function | Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalyzes prolyl peptide bond isomerization in CDC40/PRP17. Plays an important role in embryonic brain development.this function is independent of its isomerase activity. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase-Like 1PpiaseRotamase Ppil1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 proteinPpiase proteinRotamase Ppil1 proteinPPIL1 proteinCYPL1 proteinCGI-124 proteinUNQ2425 proteinPRO4984 protein |
Information sourced from Uniprot.org