Name: Human Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019731)
SKU: STJP019731
Availability: InStock

Human Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019731)

SKU:

STJP019731

£110.50 - £535.50

Short Description :	Recombinant-Human Cyclophilin F/PPIF-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:	SDS-PAGE/Enzyme Activity
Host:	E.coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration:	1 mg/mL
Formulation:	Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% Glycerol
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:	< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:	Specific activity is > 900nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin.

Gene Symbol:	PPIF
Gene ID:	10105
Uniprot ID:	PPIF_HUMAN
Accession Number:	NP_005720
Immunogen:	Human
Immunogen Region:	30-207aa
Immunogen Sequence:	MGSSHHHHHH SSGLVPRGSH MCSKGSGDPS SSSSSGNPLV YLDVDANGKP LGRVVLELKA DVVPKTAENF RALCTGEKGF GYKGSTFHRV IPSFMCQAGD FTNHNGTGGK SIYGSRFPDE NFTLKHVGPG VLSMANAGPN TNGSQFFICT IKTDWLDGKH VVFGHVKEGM DVVKKIESFG SKSGRTSKKI VITDCGQLS

Post Translational Modifications	Acetylated at Lys-167.deacetylated at Lys-167 by SIRT3.
Function	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis.the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial Ppiase F Cyclophilin D Cyp-D Cypd Cyclophilin F Mitochondrial Cyclophilin Cyp-M Rotamase F
Database Links
Cellular Localisation	Mitochondrion Matrix
Alternative Protein Names	Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial protein Ppiase F protein Cyclophilin D protein Cyp-D protein Cypd protein Cyclophilin F protein Mitochondrial Cyclophilin protein Cyp-M protein Rotamase F protein PPIF protein CYP3 protein

Information sourced from Uniprot.org

Human Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019731)

General Information

Model	Name	Host	Application
STJP019193	rat Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019193)	E.coli	SDS-PAGE
STJP019302	rat Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019302)	E.coli	SDS-PAGE/Enzyme Activity
STJP019604	Human Cyclophilin A/PPIA protein (Recombinant) (His-Tag) (STJP019604)	E.coli	SDS-PAGE/Enzyme Activity
STJP016573	Human Cyclophilin G/PPIG protein (Recombinant) (His-Tag) (STJP016573)	E.coli	SDS-PAGE/Enzyme Activity
STJP019605	Human Cyclophilin 40/PPID protein (Recombinant) (His-Tag) (STJP019605)	E.coli	SDS-PAGE/Enzyme Activity