| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Cyclin B1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNB1 |
| Gene ID: | 891 |
| Uniprot ID: | CCNB1_HUMAN |
| Immunogen Region: | 1-433aa |
| Accession Number: | NP_114172.1 |
| Immunogen: | Human |
| Immunogen Sequence: |
| Post Translational Modifications | Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Deubiquitinated by USP22 during G2/M phase. Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. |
| Function | Essential for the control of the cell cycle at the G2/M (mitosis) transition. |
| Protein Name | G2/Mitotic-Specific Cyclin-B1 |
| Database Links | Reactome: R-HSA-113507Reactome: R-HSA-156711Reactome: R-HSA-162658Reactome: R-HSA-174048Reactome: R-HSA-176408Reactome: R-HSA-176412Reactome: R-HSA-176417Reactome: R-HSA-2299718Reactome: R-HSA-2465910Reactome: R-HSA-2500257Reactome: R-HSA-2514853Reactome: R-HSA-2565942Reactome: R-HSA-2980767Reactome: R-HSA-2995383Reactome: R-HSA-3301854Reactome: R-HSA-4419969Reactome: R-HSA-6804114Reactome: R-HSA-68875Reactome: R-HSA-69273Reactome: R-HSA-69478Reactome: R-HSA-75035Reactome: R-HSA-8852276Reactome: R-HSA-8878166Reactome: R-HSA-9725371Reactome: R-HSA-9825892 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonMicrotubule Organizing CenterCentrosome |
| Alternative Protein Names | G2/Mitotic-Specific Cyclin-B1 proteinCCNB1 proteinCCNB protein |
Information sourced from Uniprot.org