| Function | Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity. |
| Protein Name | Platelet Factor 4Pf-4C-X-C Motif Chemokine 4IroplactOncostatin-A Cleaved Into - Platelet Factor 4 - Short FormEndothelial Cell Growth Inhibitor |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140875Reactome: R-HSA-202733Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-8936459 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Platelet Factor 4 proteinPf-4 proteinC-X-C Motif Chemokine 4 proteinIroplact proteinOncostatin-A Cleaved Into - Platelet Factor 4 - Short Form proteinEndothelial Cell Growth Inhibitor proteinPF4 proteinCXCL4 proteinSCYB4 protein |
Information sourced from Uniprot.org
