| Short Description : | Recombinant-Human CXCL14/BRAK-C-His protein was developed in hek293 cells using the region Met1-Glu111. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 0.5 M NaCl, 0.5 M Arginine, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CXCL14 |
| Gene ID: | 9547 |
| Uniprot ID: | CXL14_HUMAN |
| Immunogen: | Recombinant Human CXCL14/BRAK Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Glu111) of human CXCL14/BRAK (Accession #NP_004878.2) fused with a His tag at the C-terminus. |
| Immunogen Region: | Met1-Glu111 |
| Immunogen Sequence: | SKGHSIRGDNNCTHFPVSQT HMLRELRAAFSQVKTFFQKK DQLDNILLTDSLLQDFKGYL GCQALSEMIKFYLVEVMPQA ENHGPEIKEHLNSLGEKLKT LWIQLRRCHRFLPCENKSKA VEQVKNDFNKLQDKGVYKAM NEFDIFINCIEAYVTLKMKN |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. |
| Post Translational Modifications | Ubiquitinated, followed by degradation by the proteasome. |
| Function | Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. |
| Protein Name | C-X-C Motif Chemokine 14Chemokine BrakMip-2gSmall-Inducible Cytokine B14 |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-X-C Motif Chemokine 14 proteinChemokine Brak proteinMip-2g proteinSmall-Inducible Cytokine B14 proteinCXCL14 proteinMIP2G proteinNJAC proteinSCYB14 proteinPSEC0212 proteinUNQ240 proteinPRO273 protein |
Information sourced from Uniprot.org
