| Post Translational Modifications | The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide. N-glycosylated. |
| Function | Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. |
| Protein Name | Cubilin460 Kda ReceptorIntestinal Intrinsic Factor ReceptorIntrinsic Factor-Cobalamin ReceptorIntrinsic Factor-Vitamin B12 Receptor |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-3359462Reactome: R-HSA-3359463Reactome: R-HSA-8964011Reactome: R-HSA-9758881 |
| Cellular Localisation | Apical Cell MembranePeripheral Membrane ProteinCell MembraneMembraneCoated PitEndosomeLysosome MembraneLacks A Transmembrane Domain And Depends On Interaction With Amn For Location At The Plasma MembraneColocalizes With Amn And Lrp2 In The Endocytotic Apparatus Of Epithelial Cells |
| Alternative Protein Names | Cubilin protein460 Kda Receptor proteinIntestinal Intrinsic Factor Receptor proteinIntrinsic Factor-Cobalamin Receptor proteinIntrinsic Factor-Vitamin B12 Receptor proteinCUBN proteinIFCR protein |
Information sourced from Uniprot.org
