Human CTTN protein (Recombinant) (N-His) (STJP010031)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CTTN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CTTN |
| Gene ID | 2017 |
| Uniprot ID | SRC8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asn491 |
Additional Info
| Function | Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane. Plays a role in the invasiveness of cancer cells, and the formation of metastases. |
| Protein Name | Src Substrate CortactinAmplaxinOncogene Ems1 |
| Database Links | Reactome: R-HSA-5627123Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumRuffleDendriteCell MembranePeripheral Membrane ProteinCytoplasmic SidePodosomeCell JunctionFocal AdhesionMembraneClathrin-Coated PitDendritic SpineCell CortexEndoplasmic ReticulumColocalizes Transiently With Ptk2/Fak1 At Focal AdhesionsAssociated With Membrane Ruffles And LamellipodiaIn The Presence Of Cttnbp2nlColocalizes With Stress FibersIn The Presence Of Cttnbp2Localizes At The Cell CortexIn Response To Neuronal Activation By GlutamateRedistributes From Dendritic Spines To The Dendritic ShaftColocalizes With Dnm2 At The Basis Of Filopodia In Hippocampus Neuron Growth Zones |
| Alternative Protein Names | Src Substrate Cortactin proteinAmplaxin proteinOncogene Ems1 proteinCTTN proteinEMS1 protein |
Information sourced from Uniprot.org