Human CTNS protein (Recombinant) (N-His-SUMO) (STJP009043)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CTNS-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CTNS |
| Gene ID | 1497 |
| Uniprot ID | CTNS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser22-Ser120 |
Additional Info
| Function | Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. |
| Protein Name | Cystinosin |
| Database Links | Reactome: R-HSA-425393Reactome: R-HSA-5223345 |
| Cellular Localisation | Isoform 1: Lysosome MembraneMulti-Pass Membrane ProteinMelanosome MembraneAp-3 Complex Is Required For Localization To The LysosomeIsoform 2: Lysosome MembraneCell Membrane |
| Alternative Protein Names | Cystinosin proteinCTNS protein |
Information sourced from Uniprot.org