Human CTNS protein (Recombinant) (N-His-SUMO) (STJP009043)

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STJP009043
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CTNS-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CTNS
Gene ID: 1497
Uniprot ID: CTNS_HUMAN
Immunogen Region: Ser22-Ser120
Immunogen: Homo sapiens (Human)
Function Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.
Protein Name Cystinosin
Database Links Reactome: R-HSA-425393
Reactome: R-HSA-5223345
Cellular Localisation Isoform 1: Lysosome Membrane
Multi-Pass Membrane Protein
Melanosome Membrane
Ap-3 Complex Is Required For Localization To The Lysosome
Isoform 2: Lysosome Membrane
Cell Membrane
Alternative Protein Names Cystinosin protein
CTNS protein

Information sourced from Uniprot.org

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