| Tissue Specificity | Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. |
| Function | Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. |
| Protein Name | Ccn Family Member 2Cellular Communication Network Factor 2Connective Tissue Growth FactorHypertrophic Chondrocyte-Specific Protein 24Insulin-Like Growth Factor-Binding Protein 8Ibp-8Igf-Binding Protein 8Igfbp-8 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Ccn Family Member 2 proteinCellular Communication Network Factor 2 proteinConnective Tissue Growth Factor proteinHypertrophic Chondrocyte-Specific Protein 24 proteinInsulin-Like Growth Factor-Binding Protein 8 proteinIbp-8 proteinIgf-Binding Protein 8 proteinIgfbp-8 proteinCCN2 proteinCTGF proteinHCS24 proteinIGFBP8 protein |
Information sourced from Uniprot.org
