Human CRTC3 protein (Recombinant) (N-GST) (STJP005594)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CRTC3-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CRTC3 |
| Gene ID | 64784 |
| Uniprot ID | CRTC3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Phe103 |
Additional Info
| Post Translational Modifications | Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity. CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5. Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus. |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Protein Name | Creb-Regulated Transcription Coactivator 3Transducer Of Regulated Camp Response Element-Binding Protein 3Torc-3Transducer Of Creb Protein 3 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusCytoplasmAppears To Be Mainly NuclearTranslocates To The Nucleus Following Adenylyl Cyclase Or Map Kinase Activation |
| Alternative Protein Names | Creb-Regulated Transcription Coactivator 3 proteinTransducer Of Regulated Camp Response Element-Binding Protein 3 proteinTorc-3 proteinTransducer Of Creb Protein 3 proteinCRTC3 proteinTORC3 protein |
Information sourced from Uniprot.org