| Post Translational Modifications | Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity. CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5. Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus. |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Protein Name | Creb-Regulated Transcription Coactivator 3Transducer Of Regulated Camp Response Element-Binding Protein 3Torc-3Transducer Of Creb Protein 3 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusCytoplasmAppears To Be Mainly NuclearTranslocates To The Nucleus Following Adenylyl Cyclase Or Map Kinase Activation |
| Alternative Protein Names | Creb-Regulated Transcription Coactivator 3 proteinTransducer Of Regulated Camp Response Element-Binding Protein 3 proteinTorc-3 proteinTransducer Of Creb Protein 3 proteinCRTC3 proteinTORC3 protein |
Information sourced from Uniprot.org
