| Post Translational Modifications | Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. |
| Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Protein Name | Creb-Regulated Transcription Coactivator 1Mucoepidermoid Carcinoma Translocated Protein 1Transducer Of Regulated Camp Response Element-Binding Protein 1Torc-1Transducer Of Creb Protein 1 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-400253Reactome: R-HSA-9707616 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic When Phosphorylated By Sik Or Ampk And When Sequestered By 14-3-3 ProteinsTranslocated To The Nucleus On Ser-151 DephosphorylationInstigated By A Number Of Factors Including Calcium Ion And Camp LevelsLight Stimulation Triggers A Nuclear Accumulation In The Suprachiasmatic Nucleus (Scn) Of The Brain |
| Alternative Protein Names | Creb-Regulated Transcription Coactivator 1 proteinMucoepidermoid Carcinoma Translocated Protein 1 proteinTransducer Of Regulated Camp Response Element-Binding Protein 1 proteinTorc-1 proteinTransducer Of Creb Protein 1 proteinCRTC1 proteinKIAA0616 proteinMECT1 proteinTORC1 proteinWAMTP1 protein |
Information sourced from Uniprot.org
