Human CRMP1 protein (Recombinant) (N-His) (STJP005388)

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STJP005388
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CRMP1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CRMP1
Gene ID: 1400
Uniprot ID: DPYL1_HUMAN
Immunogen Region: Met1-Val250
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin.
Function Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis.
Protein Name Dihydropyrimidinase-Related Protein 1
Drp-1
Collapsin Response Mediator Protein 1
Crmp-1
Inactive Dihydropyrimidinase
Unc-33-Like Phosphoprotein 3
Ulip-3
Database Links Reactome: R-HSA-399956
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle
Cell Projection
Growth Cone
Perikaryon
Associated With Centrosomes And The Mitotic Spindle During Metaphase
Colocalizes With Flna And Tubulin In The Central Region Of Drg Neuron Growth Cone
Following Sema3a Stimulation Of Drg Neurons
Colocalizes With F-Actin
Alternative Protein Names Dihydropyrimidinase-Related Protein 1 protein
Drp-1 protein
Collapsin Response Mediator Protein 1 protein
Crmp-1 protein
Inactive Dihydropyrimidinase protein
Unc-33-Like Phosphoprotein 3 protein
Ulip-3 protein
CRMP1 protein
DPYSL1 protein
ULIP3 protein

Information sourced from Uniprot.org

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