Human CRMP1 protein (Recombinant) (His-Tag) (STJP019106)

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STJP019106
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CRMP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT, 0.2mM PMSF
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: CRMP1
Gene ID: 1400
Uniprot ID: DPYL1_HUMAN
Immunogen Region: 1-572aa
Accession Number: NP_001304
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSEFMSYQG KKSIPHITSD RLLIKGGRII NDDQSLYADV YLEDGLIKQI GENLIVPGGV KTIEANGRMV IPGGIDVNTY LQKPSQGMTA ADDFFQGTRA ALVGGTTMII DHVVPEPGSS LLTSFEKWHE AADTKSCCDY SLHVDITSWY DGVREELEVL VQDKGVNSFQ VYMAYKDVYQ MSDSQLYEAF TFLKGLGAVI LVHAENGD
Tissue Specificity Brain.
Post Translational Modifications Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin.
Function Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis.
Protein Name Dihydropyrimidinase-Related Protein 1
Drp-1
Collapsin Response Mediator Protein 1
Crmp-1
Inactive Dihydropyrimidinase
Unc-33-Like Phosphoprotein 3
Ulip-3
Database Links Reactome: R-HSA-399956
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Spindle
Cell Projection
Growth Cone
Perikaryon
Associated With Centrosomes And The Mitotic Spindle During Metaphase
Colocalizes With Flna And Tubulin In The Central Region Of Drg Neuron Growth Cone
Following Sema3a Stimulation Of Drg Neurons
Colocalizes With F-Actin
Alternative Protein Names Dihydropyrimidinase-Related Protein 1 protein
Drp-1 protein
Collapsin Response Mediator Protein 1 protein
Crmp-1 protein
Inactive Dihydropyrimidinase protein
Unc-33-Like Phosphoprotein 3 protein
Ulip-3 protein
CRMP1 protein
DPYSL1 protein
ULIP3 protein

Information sourced from Uniprot.org

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