Human CRLF2 protein (Recombinant) (His-Tag) (STJP018129)

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STJP018129
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Host: E.coli
Applications: SDS-PAGE/Denatured
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CRLF2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRLF2
Gene ID: 64109
Uniprot ID: CRLF2_HUMAN
Immunogen Region: 23-231aa
Accession Number: NP_071431
Immunogen: Human
Immunogen Sequence: QGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPP
Tissue Specificity Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
Function Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Protein Name Cytokine Receptor-Like Factor 2
Cytokine Receptor-Like 2
Il-Xr
Thymic Stromal Lymphopoietin Protein Receptor
Tslp Receptor
Database Links Reactome: R-HSA-1266695
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Cytokine Receptor-Like Factor 2 protein
Cytokine Receptor-Like 2 protein
Il-Xr protein
Thymic Stromal Lymphopoietin Protein Receptor protein
Tslp Receptor protein
CRLF2 protein
CRL2 protein
ILXR protein
TSLPR protein

Information sourced from Uniprot.org

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