Human CREB3L3 protein (Recombinant) (N-His) (STJP005568)

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STJP005568
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CREB3L3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CREB3L3
Gene ID: 84699
Uniprot ID: CR3L3_HUMAN
Immunogen Region: Met1-Thr322
Immunogen: Homo sapiens (Human)
Post Translational Modifications Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). N- and O-glycosylated. N-glycosylation is required for optimal proteolytic activation. O-glycosylated with core 1 or possibly core 8 glycans. Ubiquitinated at Lys-294 by SYNV1/HRD1 via 'Lys-27'-linked ubiquitin.
Function Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription. Plays a crucial role in the regulation of triglyceride metabolism and is required for the maintenance of normal plasma triglyceride concentrations.
Protein Name Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3
Camp-Responsive Element-Binding Protein 3-Like Protein 3
Transcription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3
Database Links Reactome: R-HSA-8874211
Reactome: R-HSA-8963889
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3: Nucleus
Under Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus
Alternative Protein Names Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 protein
Camp-Responsive Element-Binding Protein 3-Like Protein 3 protein
Transcription Factor Creb-H Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 3 protein
CREB3L3 protein
CREBH protein
HYST1481 protein

Information sourced from Uniprot.org

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