Human CREB3L2 protein (Recombinant) (N-His) (STJP008928)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CREB3L2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CREB3L2 |
| Gene ID | 64764 |
| Uniprot ID | CR3L2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala245-Leu380 |
Additional Info
| Post Translational Modifications | Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). N-glycosylated. Ubiquitinated by HRD1/SYVN1.undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized. |
| Function | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2Camp-Responsive Element-Binding Protein 3-Like Protein 2Bbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinEr Membrane Resident ProteinUpon Er StressTranslocated To The Golgi Apparatus Where It Is CleavedThe Cytosolic N-Terminal Fragment (Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 1) Is Transported Into The NucleusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2: NucleusTranslocated Into The Nucleus |
| Alternative Protein Names | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 proteinCamp-Responsive Element-Binding Protein 3-Like Protein 2 proteinBbf2 Human Homolog On Chromosome 7 Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 2 proteinCREB3L2 proteinBBF2H7 protein |
Information sourced from Uniprot.org