| Tissue Specificity | Ubiquitous. Most prevalent in testis. |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc9Rna Polymerase Iii Subunit C9Calcitonin Gene-Related Peptide-Receptor Component ProteinCgrp-RcpCgrp-Receptor Component ProteinCgrprcpHsc17 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | NucleusCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Dna-Directed Rna Polymerase Iii Subunit Rpc9 proteinRna Polymerase Iii Subunit C9 proteinCalcitonin Gene-Related Peptide-Receptor Component Protein proteinCgrp-Rcp proteinCgrp-Receptor Component Protein proteinCgrprcp proteinHsc17 proteinCRCP protein |
Information sourced from Uniprot.org
