Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
Database Links | Reactome: R-HSA-6803207 |
Cellular Localisation | CytoplasmNucleus |
Alternative Protein Names | Death Domain-Containing Protein Cradd proteinCaspase And Rip Adapter With Death Domain proteinRip-Associated Protein With A Death Domain proteinCRADD proteinRAIDD protein |
Information sourced from Uniprot.org