| Function | Isoform 1: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Isoform 2: Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli. During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function. Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47. Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation. In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways. Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function. Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. |
| Protein Name | Ef-Hand Calcium-Binding Domain-Containing Protein 4bCalcium Release-Activated Calcium Channel Regulator 2aCrac Channel Regulator 2aCalcium Release-Activated Channel Regulator 2aRas-Related Protein Rab-46 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 2: CytoplasmCytoplasmCytoskeletonMicrotubule Organizing CenterCell MembraneGolgi Apparatus MembraneGolgi ApparatusTrans-Golgi Network MembraneVesicleT-Cell Activation-Induced Elevation Of Intracellular Of Ca(2+) Stimulates Its Transport Toward The Microtubule Organizing Center (Mtoc)Histamine Stimulation Induces A Trafficking To The Mtoc In A Gtp-Binding-Dependent But Ca(2+)-Binding-Independent MannerLocalizes To Golgi Membrane In Resting T-Cells And Upon Its Interaction With Vav1Is Translocated From The Golgi Membrane To The Immunological Synapse Via Subsynaptic VesiclesIts Localization In The Golgi Membrane Requires Isoprenylation And Gtp-Binding |
| Alternative Protein Names | Ef-Hand Calcium-Binding Domain-Containing Protein 4b proteinCalcium Release-Activated Calcium Channel Regulator 2a proteinCrac Channel Regulator 2a proteinCalcium Release-Activated Channel Regulator 2a proteinRas-Related Protein Rab-46 proteinCRACR2A proteinEFCAB4B proteinRAB46 protein |
Information sourced from Uniprot.org
