Human CORO1C protein (Recombinant) (N-His) (STJP016367)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CORO1C-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CORO1C |
| Gene ID | 23603 |
| Uniprot ID | COR1C_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Arg352 |
Additional Info
| Function | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells. Isoform 3: Involved in myogenic differentiation. |
| Protein Name | Coronin-1cCoronin-3Hcrnn4 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumRuffle MembraneCytoplasmCytoskeletonCell CortexEndosome MembraneAll Isoforms Colocalize With The Actin Cytoskeleton In The CytosolAnd Especially In The Cell CortexColocalizes With F-Actin At The Leading Edge Of LamellipodiaPartially Colocalizes With Microtubules And Vimentin Intermediate FilamentsLocalizes To Endosome Membrane Tubules/BudsIsoform 3: Cell MembraneSarcolemmaMyofibrilSarcomereSynapseColocalizes With The Thin Filaments Of The Sarcomere And With The Postsynaptic Area And The Junctional Sarcoplasm Of Motor End PlatesColocalizes With The Actin Cytoskeleton In The Cytosol |
| Alternative Protein Names | Coronin-1c proteinCoronin-3 proteinHcrnn4 proteinCORO1C proteinCRN2 proteinCRNN4 protein |
Information sourced from Uniprot.org