| Function | FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown. |
| Protein Name | Ubiquinone Biosynthesis Monooxygenase Coq6 - MitochondrialCoenzyme Q10 Monooxygenase 6 |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideGolgi ApparatusCell ProjectionLocalizes To Cell Processes And Golgi Apparatus In Podocytes |
| Alternative Protein Names | Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial proteinCoenzyme Q10 Monooxygenase 6 proteinCOQ6 proteinCGI-10 protein |
Information sourced from Uniprot.org
