Human COQ6 protein (Recombinant) (N-His) (STJP006253)

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STJP006253
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Short Description :Recombinant-Human COQ6-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:COQ6
Gene ID:51004
Uniprot ID:COQ6_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Lys468
Function FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR.
Protein Name Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial
2-Methoxy-6-Polyprenolphenol 4-Hydroxylase
Coenzyme Q10 Monooxygenase 6
Database Links Reactome: R-HSA-2142789
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Matrix Side
Golgi Apparatus
Cell Projection
Localizes To Cell Processes And Golgi Apparatus In Podocytes
Alternative Protein Names Ubiquinone Biosynthesis Monooxygenase Coq6 - Mitochondrial protein
2-Methoxy-6-Polyprenolphenol 4-Hydroxylase protein
Coenzyme Q10 Monooxygenase 6 protein
COQ6 protein
CGI-10 protein

Information sourced from Uniprot.org

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