| Tissue Specificity | Widely expressed. |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. |
| Protein Name | Cop9 Signalosome Complex Subunit 6Sgn6Signalosome Subunit 6Jab1-Containing Signalosome Subunit 6Mov34 HomologVpr-Interacting ProteinHvip |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | NucleusCytoplasmPerinuclear Region(Microbial Infection) The Interaction With Hiv-1 Vpr Protein Possibly Leads Its Translocation To A Perinuclear Region |
| Alternative Protein Names | Cop9 Signalosome Complex Subunit 6 proteinSgn6 proteinSignalosome Subunit 6 proteinJab1-Containing Signalosome Subunit 6 proteinMov34 Homolog proteinVpr-Interacting Protein proteinHvip proteinCOPS6 proteinCSN6 proteinHVIP protein |
Information sourced from Uniprot.org
