Tissue Specificity | |
Post Translational Modifications | |
Function | Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation. |
Protein Name | Coordinator Of Prmt5 And Differentiation StimulatorCooperator Of Prmt5Protein Ttp1 |
Database Links | Reactome: R-HSA-3214858 |
Cellular Localisation | Nucleus |
Alternative ELISA Names | Coordinator Of Prmt5 And Differentiation Stimulator ELISA kitCooperator Of Prmt5 ELISA kitProtein Ttp1 ELISA kitCOPRS ELISA kitC17orf79 ELISA kitCOPR5 ELISA kit |
output | |
Information sourced from Uniprot.org