| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | CNTN2 |
| Gene ID: | 6900 |
| Uniprot ID: | CNTN2_HUMAN |
| Immunogen: | Recombinant Human Contactin 2/CNTN2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser31-Asn1012) of human Contactin 2/CNTN2 (Accession #NP_005067.1 ) fused with an 8×His tag at the C-terminus. |
| Immunogen Sequence: | SQTTFGPVFEDQPLSVLFPE ESTEEQVLLACRARASPPAT YRWKMNGTEMKLEPGSRHQL VGGNLVIMNPTKAQDAGVYQ CLASNPVGTVVSREAILRFG FLQEFSKEERDPVKAHEGWG VMLPCNPPAHYPGLSYRWLL NEFPNFIPTDGRHFVSQTTG NLYIARTNASDLGNYSCLAT SHMDFSTKSVFSKFAQLNLA AEDTRLFAPSIKARFPAETY ALVGQQVTLECFAFGNPVP |
| Function | In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. |
| Protein Name | Contactin-2Axonal Glycoprotein Tag-1Axonin-1Transient Axonal Glycoprotein 1Tax-1 |
| Database Links | Reactome: R-HSA-373760Reactome: R-HSA-419037Reactome: R-HSA-447038 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAttached To The Neuronal Membrane By A Gpi-Anchor And Is Also Released From Neurons |
| Alternative Protein Names | Contactin-2 proteinAxonal Glycoprotein Tag-1 proteinAxonin-1 proteinTransient Axonal Glycoprotein 1 proteinTax-1 proteinCNTN2 proteinAXT proteinTAG1 proteinTAX1 protein |
Information sourced from Uniprot.org