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SDS-PAGE gel of recombinant human Complement Factor D protein under reducing conditions

Human Complement Factor D protein (Recombinant) (His-Tag) (STJP017984)

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STJP017984
£100.50 - £738.50
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Short Description :Recombinant-Human Complement Factor D-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Denatured
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.4M urea
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:CFD
Gene ID:1675
Uniprot ID:CFAD_HUMAN
Accession Number:NP_001919
Immunogen:Human
Immunogen Region:26-253aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MILGGREAEA HARPYMASVQ LNGAHLCGGV LVAEQWVLSA AHCLEDAADG KVQVLLGAHS LSQPEPSKRL YDVLRAVPHP DSQPDTIDHD LLLLQLSEKA TLGPAVRPLP WQRVDRDVAP GTLCDVAGWG IVNHAGRRPD SLQHVLLPVL DRATCNRRTH HDGAITERLM CAESNRRDSC KGDSGGPLVC GGVLEGVVTS GSRVCGNR
Post Translational Modifications CFD is activated by the removal of 5 residues at the N-terminus, named activation peptide, by the MASP-3 isoform of MASP1.
Function Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway.
Protein Name Complement Factor D
Adipsin
C3 Convertase Activator
Properdin Factor D
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-173736
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Protein Names Complement Factor D protein
Adipsin protein
C3 Convertase Activator protein
Properdin Factor D protein
CFD protein
DF protein
PFD protein

Information sourced from Uniprot.org

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