Recombinant Human Complement C5A Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 10-15kDa.

Human Complement C5A protein (Recombinant) (C-His) (STJP002921)

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STJP002921
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Host: E.coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/ug of the protein by LAL method.
Immunoreactivity: Measured by its ability to induce N-acetyl-Beta-D-glucosaminidase release from differentiated U937 human histiocytic lymphoma cells. The ED50 for this effect is typically 5-15 ng/mL.
Gene Symbol: C5
Gene ID: 727
Uniprot ID: CO5_HUMAN
Immunogen Region: Thr678-Arg751
Immunogen: Recombinant Human Complement C5A Protein is produced by E. coli expression system. The target protein is expressed with sequence (Thr678-Arg751) of Human Complement C5A (Accession #NP_001726.2) fused with no tag.
Immunogen Sequence: ALPEDGGAAFPPGHFKDPKR LYCKNGGFFLRIHPDGRVDG VREKSDPHVKLQLQAEERGV VSIKGVCANRYLAMKEDGRL LASKCVTEECFFFERLESNN YNTYRSRKYSSWYVALKRTG QYKLGSKTGPGQKAILFLPM SAKS
Function Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. C5a anaphylatoxin: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Protein Name Complement C5
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 Cleaved Into - Complement C5 Beta Chain - Complement C5 Alpha Chain - C5a Anaphylatoxin - Complement C5 Alpha' Chain
Database Links Reactome: R-HSA-166665
Reactome: R-HSA-174577
Reactome: R-HSA-375276
Reactome: R-HSA-418594
Reactome: R-HSA-977606
Cellular Localisation Secreted
Alternative Protein Names Complement C5 protein
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 Cleaved Into - Complement C5 Beta Chain - Complement C5 Alpha Chain - C5a Anaphylatoxin - Complement C5 Alpha' Chain protein
C5 protein
CPAMD4 protein

Information sourced from Uniprot.org

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