Human COMP (Cartilage Oligomeric Matrix Protein) Antibody Pair (STJAP00241)

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STJAP00241-50
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Host: Mouse/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This COMP antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A.
Detection Purification: Protein A & Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: COMP
Gene ID: 1311
Uniprot ID: COMP_HUMAN
Immunogen: Capture immunogen: Recombinant Human COMP protein.
Detection Immunogen: Recombinant Human COMP protein.
Function Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Protein Name Cartilage Oligomeric Matrix Protein
Comp
Thrombospondin-5
Tsp5
Database Links Reactome: R-HSA-216083
Reactome: R-HSA-3000178
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Pair Names Cartilage Oligomeric Matrix Protein antibody pair
Comp antibody pair
Thrombospondin-5 antibody pair
Tsp5 antibody pair
COMP antibody pair

Information sourced from Uniprot.org

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