| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | COL1A1 |
| Gene ID: | 1277 |
| Uniprot ID: | CO1A1_HUMAN |
| Immunogen Region: | Asp1219-Leu1464 |
| Immunogen: | Recombinant Human Collagen I alpha 1/COL1A1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp1219-Leu1464 ) of Human Collagen I alpha 1/COL1A1 (Accession #NP_000079.2) fused with hFc tag at the |
| Immunogen Sequence: | RPHGDTAKKPIIGILMQKCR NKVMKNYGRYYIAASYVKYL ESAGARVVPVRLDLTEKDYE ILFKSINGILFPGGSVDLRR SDYAKVAKIFYNLSIQSFDD GDYFPVWGTCLGFEELSLLI SGECLLTATDTVDVAMPLNF TGGQLHSRMFQNFPTELLLS LAVEPLTANFHKWSLSVKNF TMNEKLKKFFNVLTTNTDGK IEFISTMEGYKYPVYGVQWH PEKAPYEWKNLDGISHAPN |
| Tissue Specificity | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. |
| Post Translational Modifications | Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. |
| Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Protein Name | Collagen Alpha-1(I ChainAlpha-1 Type I Collagen |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1442490Reactome: R-HSA-1474244Reactome: R-HSA-1650814Reactome: R-HSA-198933Reactome: R-HSA-2022090Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-2214320Reactome: R-HSA-2243919Reactome: R-HSA-3000170Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-3000480Reactome: R-HSA-430116Reactome: R-HSA-75892Reactome: R-HSA-76009Reactome: R-HSA-8874081Reactome: R-HSA-8940973Reactome: R-HSA-8948216Reactome: R-HSA-9845619Reactome: R-HSA-9845620Reactome: R-HSA-9845621Reactome: R-HSA-9845622Reactome: R-HSA-9846298 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Collagen Alpha-1(I Chain proteinAlpha-1 Type I Collagen proteinCOL1A1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
