| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Coactosin-like 1/COTL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT, 0.1M NaCl. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COTL1 |
| Gene ID: | 23406 |
| Uniprot ID: | COTL1_HUMAN |
| Immunogen Region: | 1-142aa |
| Accession Number: | NP_066972.1 |
| Immunogen: | Human |
| Immunogen Sequence: |
| Tissue Specificity | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. |
| Function | Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. |
| Protein Name | Coactosin-Like Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoskeletonNucleus |
| Alternative Protein Names | Coactosin-Like Protein proteinCOTL1 proteinCLP protein |
Information sourced from Uniprot.org
