Human CNOT9 protein (Recombinant) (N-His) (STJP008347)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CNOT9-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CNOT9 |
| Gene ID | 9125 |
| Uniprot ID | CNOT9_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr12-Glu285 |
Additional Info
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 9Cell Differentiation Protein Rqcd1 HomologRcd-1 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-5617472Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | NucleusCytoplasmP-BodyNanos2 Promotes Its Localization To P-Body |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 9 proteinCell Differentiation Protein Rqcd1 Homolog proteinRcd-1 proteinCNOT9 proteinRCD1 proteinRQCD1 protein |
Information sourced from Uniprot.org