| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 8Caf1-Like ProteinCalifpCaf2Ccr4-Associated Factor 8Caf1b |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Ccr4-Not Transcription Complex Subunit 8 proteinCaf1-Like Protein proteinCalifp proteinCaf2 proteinCcr4-Associated Factor 8 proteinCaf1b proteinCNOT8 proteinCALIF proteinPOP2 protein |
Information sourced from Uniprot.org
