Human CNGA3 protein (Recombinant) (N-His) (STJP016287)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CNGA3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | CNGA3 |
| Gene ID | 1261 |
| Uniprot ID | CNGA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Phe503-Gln694 |
Additional Info
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-3Cng Channel Alpha-3Cng-3Cng3Cone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Cyclic Nucleotide-Gated Channel Alpha-3 proteinCng Channel Alpha-3 proteinCng-3 proteinCng3 proteinCone Photoreceptor Cgmp-Gated Channel Subunit Alpha-3 proteinCNGA3 proteinCNCG3 protein |
Information sourced from Uniprot.org