Human CLTRN protein (Recombinant) (N-His) (STJP006017)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human CLTRN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CLTRN |
| Gene ID | 57393 |
| Uniprot ID | CLTRN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys17-Asp137 |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN. Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125.the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites. |
| Function | Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication. |
| Protein Name | CollectrinTransmembrane Protein 27 |
| Database Links | Reactome: R-HSA-264876 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalizes To The Brush Border Membranes Of Cells In The Proximal Tubules Of KidneyColocalizes With Slc6a19 In The Early Proximal S1 Tubule |
| Alternative Protein Names | Collectrin proteinTransmembrane Protein 27 proteinCLTRN proteinTMEM27 proteinUNQ679 proteinPRO1312 protein |
Information sourced from Uniprot.org