Human CLIC3 protein (Recombinant) (C-His) (STJP014312)

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STJP014312-100
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Host: E.coli
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLIC3-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 200mM Sucrose, 0.05% Tween 80 (w/v) , pH 8.5.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: CLIC3
Gene ID: 9022
Uniprot ID: CLIC3_HUMAN
Immunogen Region: Met1-Arg236
Immunogen: Homo sapiens (Human)
Function In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control.
Protein Name Chloride Intracellular Channel Protein 3
Glutaredoxin-Like Oxidoreductase Clic3
Database Links
Cellular Localisation Nucleus
Membrane
Single-Pass Membrane Protein
Cell Membrane
Cytoplasm
Secreted
Extracellular Space
Extracellular Matrix
Predominantly Nuclear
Some Protein Was Found In The Cytoplasm
Exists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane Domain
Secreted Into The Extracellular Matrix By Activated Fibroblasts
Alternative Protein Names Chloride Intracellular Channel Protein 3 protein
Glutaredoxin-Like Oxidoreductase Clic3 protein
CLIC3 protein

Information sourced from Uniprot.org