Human CLEC6A protein (Recombinant-Active) (N-His) (STJP012159)

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STJP012159-100
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Short Description :Recombinant-Active-Human CLEC6A-N-His protein was developed from mammalian cells and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:Mammalian Cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Dilution Range:Reconstitute in sterile water for a stock solution.
Formulation:Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity:Measured by its ability to bind biotinylated alpha-D Mannose-PAA in a functional ELISA.
Gene Symbol:CLEC6A
Gene ID:93978
Uniprot ID:CLC6A_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Thr46-Leu209
Function Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
Protein Name C-Type Lectin Domain Family 6 Member A
C-Type Lectin Superfamily Member 10
Dendritic Cell-Associated C-Type Lectin 2
Dc-Associated C-Type Lectin 2
Dectin-2
Database Links Reactome: R-HSA-5621480
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names C-Type Lectin Domain Family 6 Member A protein
C-Type Lectin Superfamily Member 10 protein
Dendritic Cell-Associated C-Type Lectin 2 protein
Dc-Associated C-Type Lectin 2 protein
Dectin-2 protein
CLEC6A protein
CLECSF10 protein
DECTIN2 protein

Information sourced from Uniprot.org

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