Human CLCN7 protein (Recombinant) (N-His) (STJP011409)

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STJP011409
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human CLCN7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: CLCN7
Gene ID: 1186
Uniprot ID: CLCN7_HUMAN
Immunogen Region: Phe597-Thr805
Immunogen: Homo sapiens (Human)
Function Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
Protein Name H(+/Cl(- Exchange Transporter 7
Chloride Channel 7 Alpha Subunit
Chloride Channel Protein 7
Clc-7
Database Links Reactome: R-HSA-2672351
Cellular Localisation Lysosome Membrane
Multi-Pass Membrane Protein
Alternative Protein Names H(+/Cl(- Exchange Transporter 7 protein
Chloride Channel 7 Alpha Subunit protein
Chloride Channel Protein 7 protein
Clc-7 protein
CLCN7 protein

Information sourced from Uniprot.org

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